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Image Search Results
Journal: Oncotarget
Article Title: Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability
doi: 10.18632/oncotarget.12320
Figure Lengend Snippet: Four days after inoculation, HCT-116 and HT29 spheroids with a mean diameter of ~400 μm were exposed to specific treatment conditions without ( A ) or with ( B ) canavanine for 5 days prior to single dose irradiation. The percentage of spheroids that lost regrowth capacity (spheroid control probability, SCP) is shown as a function of irradiation dose. n = 30–40 individual spheroids per condition were monitored over a period of 60 days post-treatment. Treatment conditions: –Arg – arginine-free medium; +Arg medium was obtained by supplementation of –Arg conditions with 0.4 mM Arg and used as control; Cav – 0.1 mM Cav; SCD 50 – spheroid control dose 50 .
Article Snippet: The
Techniques: Irradiation